Comparison of the effect of tetracycline gel and gel containing mesoporous silica nanoparticles loaded with tetracycline on reducing microbial infection at the junction of implant and abutment

Not Applicable

Recruiting

Conditions: periodontitis.
Post-osseointegration biological failure of dental implant
M27.62

Registration Number: IRCT20210306050605N1

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 15

Inclusion Criteria

1- Having at least 3 implants in one jaw
2- Having a minimum age of 18 years
3- The depth of the probe around the implant is between 1-3 mm (height of the abutment heel inside the gingiva is maximum 3 mm)
4- Possibility of placing zirconia crown with upper gingival margin
5- At least 4 months have passed since the extraction of the replacement teeth.

Exclusion Criteria

1- Pregnant and lactating women
2- Patients receiving antibiotics in the last 6 months
3- Having any systemic disease such as diabetes that affects oral health
4- Addiction to drugs, cigarettes or alcohol
5-History of allergy to tetracycline
6- Based on the flowchart of diagnosis of covid 19 in the levels of outpatient services for definite people with coronary heart disease and suspected of it (1. History of dry cough or chills or sore throat with shortness of breath with or without fever, which can be justified by another etiological factor 2. A patient with fever or respiratory symptoms (whatever the severity): A. Have a history of close contact with a probable / definite case of covid 19 within 14 days prior to the onset of symptoms. Health personnel)
7- Patients with bone thickness less than 5 mm in cbct and patients need graft and bone reconstruction
8- Presence of periodontal disease in other

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Measurement of the amount of bacteria after placing tetracycline gel and gel containing tetracycline-loaded nanoparticles in the implant for three times. Timepoint: 10 days 15 days 30 days after placing the sample. Method of measurement: Bacterial colony counting method.

Secondary Outcome Measures