Efficacy of prophylactic adminstration of diphenhydramine and dexmedetomidine during anesthesia on emergence agitation and quality of recovery after Orthognathic surgeries.
Phase 2
- Conditions
- Sedation and analgesia effects of diphenhydramine and dexmedetomidine in orthognathic surgery.
- Registration Number
- IRCT20130304012695N19
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Age 18-60 years
patients candidate for orthognathic surgery
Consent to participate in the study
Exclusion Criteria
Uncontrolled diabetes
Uncontrolled blood pressure
Glaucoma disease
Any allergy to antihistamines
Opiods drug adiction
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.;Severity of postoperative pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Hemodynamic changes. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Blood pressure and Heart Rate.
- Secondary Outcome Measures
Name Time Method