Validation of the Use of Istope-Based Molecular Techniques for Malaria Control
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 试验地点
- 1
- 主要终点
- Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages
研究概览
简要总结
The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 1 Year 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All residents of the 8 villages
排除标准
- •Pregnancy
- •History of allergy to sulfa drugs
研究组 & 干预措施
1
1:Active comparator sulfadoxine-pyrimethamine plus artesunate
干预措施: Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS) (Drug)
2
2:placebo comparator
干预措施: placebo tablet similar to active drug in shape and size (Drug)
结局指标
主要结局
Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages
时间窗: October to December 2006
次要结局
- 1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes