Comparison of single and combination diuretics in low-renin hypertension - Pathway 3

Cambridge University Hospitals NHS Foundation Trust and University of0 sites486 target enrollmentApril 16, 2009

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Not specified
Sponsor: Cambridge University Hospitals NHS Foundation Trust and University of
Enrollment: 486
Status: Active, not recruiting
Last Updated: 14 years ago

No summary available.

Registry

who.int

Start Date

April 16, 2009

End Date

TBD

Last Updated

14 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

Cambridge University Hospitals NHS Foundation Trust and University of

•Each of the following conditions must be satisfied. Patients can proceed to placebo run\-in if biochemical data is available from previous 6 months, but cannot proceed to randomised treatment if eligibility not confirmed by baseline sample:
•1\. Age 18\-79
•2\. Diagnosis of hypertension according to BHS criteria
•3\. Clinic seated SBP (mean of 2nd \& 3rd readings after 10 minutes rest) on permitted background treatment \>\= 145 mmHg
•4\. Indication for diuretic treatment:
•(a) Untreated \+ (age\>55 AND/OR Black AND/OR renin\<12mU/L)
•OR (b) receiving ACEI/ARB
•OR (c) receiving CCB
•OR (d) receiving ACEI/ARB \+ CCB
•5\. At least one other component (i.e. additional to hypertension) of the metabolic syndrome (reduced HDL, raised triglycerides, glucose, waist circumference)\*

•Exclusions :
•The presence of any of the following will preclude patient inclusion
•Diabetes (types 1 or 2\)
•Secondary hypertension
•eGFR \< 60 mls/min
•Plasma K\+ outside normal range on two successive measurements during screening
•Home SBP at the end of placebo run\-in \>170 mmHg
•Home DBP at the end of placebo run\-in \>115 mmHg
•Requirement for treatment with \>2 drugs (which can be a CCB and/or {ACEi OR ARB OR ß\-blocker}) in order to reduced blood pressure to \=170/115 mmHg
•Requirement for diuretic therapy (other than for hypertension)