Can Dynamic Contrast Enhanced Computed Tomography (DCE-CT) scans aid in the diagnosis of early stage lung cancer and are they cost effective?

Not Applicable

Completed

• Conditions: Diagnosis of early stage lung cancer in a population that have a single pulmonary nodule detected by conventional CT scan; Cancer; Malignant neoplasm of bronchus and lung

• Registration Number: ISRCTN30784948
• Lead Sponsor: niversity Hospital Southampton NHS Foundation Trust (UK)

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33130961/ results (added 03/11/2020) 2016 Protocol article in https://pubmed.ncbi.nlm.nih.gov/27843550/ protocol (added 17/12/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35289267/ Health Technology Assessment programme results publication (added 16/03/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-30
• Study Completion: 2019-04-30
• Last Update Posted: 28 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 355

Inclusion Criteria

1. A soft tissue solitary dominant pulmonary nodule of = 8mm and = 30mm on axial plane, measured on lung window using conventional CT scan with no other ancillary evidence strongly indicative of malignancy (e.g. distant metastases) or unequivocal local invasion.
2. 18 years of age or over at time of providing consent
3. Able and willing to consent to study

Exclusion Criteria

1. Pregnancy
2. History of malignancy within the past 2 years
3. Confirmed aetiology of the nodule
4. Biopsy of nodule prior to DCE-CT scan
5. Contra-indication to potential radiotherapy or surgery
6. Contra indication to scans (assessed by local procedures)

Study & Design

• Study Type: Observational
• Study Design: Not specified