Comprehensive and longitudinal study for neurodegenerative dementia using [11C]PBB3 positron emission tomography

Not Applicable

Recruiting

• Conditions: The dementia includes mild cognitive impairment, Alzheimer' s disease, frontemporal degeneration, Lewy body disease, Parkinson' s disease with dementia, corticobasal degeneration, progressive supranuclear palsy. Morever, subjects with hypertension, hyperglycemia (diabetes), and hyperlipidemia, which associate with dementia, are also included.

• Registration Number: JPRN-UMIN000017978
• Lead Sponsor: ational Institute of Radiological Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-19
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

Not provided

Exclusion Criteria

The subject who have already took part in the previous examination in the study of dementia using [11C]PBB3 PET imaging in a year is excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The association of the changes observed in amyloid imaging ([11C]PIB-PET) and tau imaging ([11C]PBB3-PET) with their clinical progression of the disease such as their cognitive decline.

Secondary Outcome Measures

Name	Time	Method
The contribution of risk factor such as hypertension, hyperglycemia (diabetes), and hyperlipidemia to the cerebral amyloid/tau load or the pathophysiology of the dementia.