Assessing the effectiveness of cold local anesthesia in management of acute tooth pain

Phase 2/3

Completed

• Conditions: ASA Category 1; Symptomatic irreversible pulpitis,Hot tooth

• Registration Number: CTRI/2018/03/012834
• Lead Sponsor: Ishwarya Gurucharan

Brief Summary

Achieving profound pulpal anesthesia in endodontics is a challenging task, particularly, in cases of acutely inflamed teeth. When conventional primary anesthetic techniques fail, there might be a need for a supplemental anesthesia. Local anesthetic(LA) administration may also add to patient’s discomfort. Cold application to a localized area to block the pain impulses is referred to as “Cryoanesthesiaâ€, which is widely practiced in the field of medicine. One of the strategies to reduce pain perception during local anesthetic administration is precooling the injection site, as stated by Ghaderi *et al*.(2013) Further, use of cooled anesthetic solution to enhance pulpal anesthesia is attributed to an increase in affinity of the charged anesthetic molecule to nerve receptors. However, the effect of refrigerated 2% lignocaine HCl for maxillary infiltration anesthesia in molars has not been evaluated yet. Hence, the aim of the present study is to assess the effects of precooling the injection site and administration of cold 2% lignocaine HCl (8-10oC) in symptomatic irreversible pulpitis of maxillary molars and also to compare the pain on injection, onset of action and anesthetic efficacy achieved with that of 2% lignocaine HCl (room temperature), with and without precooling the injection site. The experimental groups are:

**Group 1**: Precooling the injection site and cold 2% lignocaine HCl.

**Group 2**: LA gel with 2% lignocaine HCl (room temperature)

Pain score will be assessed using Heft Parker scale (VAS) and other parameters will be assessed using EPT.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-04
• Study Completion: 2019-02-15
• Last Update Posted: 2022-02-07

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Healthy adult patients aged 18 to 45 years who are willing to give informed consent Teeth with acute and spontaneous pain Patients with symptomatic irreversible pulpitis in maxillary molars of both the quadrants Presence of vital tissue on access opening.

Exclusion Criteria

Allergic to Local anesthetics Medically compromised patients (ASA Class III or higher) Patients under medication which may affect the pain assessment Inability to give informed consent Teeth with presence of Periapical radiolucencies presence of active pathosis in the injection site vertical fractures periodontally compromised teeth nonrestorable teeth.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduced pain on injection	Onset - 1 minute after injection of anesthesia
Faster onset of pulpal anesthesia	Onset - 1 minute after injection of anesthesia

Secondary Outcome Measures

Name	Time	Method
Greater anesthetic efficacy	15 minutes

Trial Locations

Locations (1)

SRM dental college; 🇮🇳 Chennai, TAMIL NADU, India

SRM dental college

🇮🇳Chennai, TAMIL NADU, India

Ishwarya Gurucharan

Principal investigator

9840377323

sriish@gmail.com