Development of diagnostic and treatment strategy for resistant hypertensio
Not Applicable
Recruiting
- Conditions
- Diseases of the circulatory system
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 780
Inclusion Criteria
1. 20 years and older
2. Office SBP>130 mmHg or office DBP >90 mmHg with 3 antihypertensive medications of different classes
3. Treated hypertensive patients with 4 antihypertensive medications of difference classes including diuretics
Exclusion Criteria
1. desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
2. women with pregnancy or on nursing
3. within the first three months after transplantation
4. acute renal allograft rejection
5. within six months after dicharge from hospitalization for acute coronary syndrome (myocardial infarction, unstable angina) or acute stroke
6. systolic heart failure (LVEF =40%)
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method "Outcome, Multiple item"_Composite of cardiovascular death, myocardial infarction, stroke, admission for heart failure
- Secondary Outcome Measures
Name Time Method 1. Progression of CKD: Start dialysis or doubling of serum creatinine, Target organ damage: LVH confirmed by echocardiography or EKG; carotid femoral PWV= 12m/s; microalbuminuria (Urine albumin-creatinine ratio =30 mg/g),Target blood pressure: Achievement of BP below 130/80 or 140/90 mmHg