Biasing approach/avoidance decisions using Transcranial Ultrasonic Stimulation of the Human Amygdala ventral Striatum

• Conditions: brain; anxiety; 10002861

• Registration Number: NL-OMON51624
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 85

Inclusion Criteria

- Healthy participants between 18-40 years of age;
- The ability and agreement to provide informed consent, and the ability to
fulfil the study's requirements.

Exclusion Criteria

•Under 18 years of age
•Current or planned pregnancy
•Claustrophobia
•A history or brain surgery or serious head trauma
•A history of or any close relatives (parents, siblings, children) with
epilepsy, convulsion, or seizure
•Predisposition for fainting spells (syncope)
•A cardiac pacemaker or intra-cardiac lines
•An implanted neurostimulator
•Implanted medication infusion device
•Implanted metal devices or large ferromagnetic fragments in the head or upper
body (excluding dental wire),or jewellery/piercing that cannot be removed
•Use of a medical plaster that cannot or may not be taken off (e.g., nicotine
plaster)
•Cochlear implants
•Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.)
•Diagnosed neurological or psychiatric disorders
•Use of psychoactive (prescription) medication (excluding anti-conception)
•Skin disease at intended stimulation sites
•The consumption of more than four alcoholic units within 24 hours before
participation or any recreational drugs within 48 hours before participation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Approach/avoidance choice behaviour as indicated by index-finger button-press<br /><br>will be used to assess the neuromodulatory effects of TUS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Pupil size; Heart rate.<br /><br>These secondary study parameters fall under the blanket approval for standard<br /><br>research (CMO2014/288, version 3; titled: *Imaging Human Cognition*).</p><br>