Adipose tissue oxygen tension: adipose tissue depot differences and functional consequences - Adipose tissue depot differences in oxygen tension

niversiteit Maastricht0 个研究点目标入组 14 人开始时间: 待定最近更新: 2024年4月29日

试验速览

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•- Woman with overweight/obesity (body mass index >= 28 kg/m2) and a disturbed glucose metabolism (IFG: 6.1-7.0 mmol/l (or 5.6-7.0 mmol/l and a family history of diabetes) and/or IGT: 2h plasma glucose during OGTT 7.8-11.1 mmol/l)
•- postmenopausal
•- Age: 40-65
•- Non smoking
•- A stable bodyweight for at least 3 months (no change in bodyweight: < 3kg)

•- diabetes mellitus
•- cardiovascular diseases
•- asthma or bronchitis
•- liver and/or kidney disease (determined based on ALAT and creatinine levels, respectively)
•- a disease with a life expectancy < 5 years (will be questioned for each individual)
•- alcohol and/or drug abuse (alcohol consumption > 15 units/week)
•- plans to lose weight (subjects will be asked if they have weight loss plans (e.g. to increase their physical activity level or change diet): a positive answer will lead to exclusion)
•- participation in sport activities for more than 3 hours/week
•- Usage of higher doses anti-oxidants (vitamin A, C, E, beta-carteen; standard multi-vitamin supplements are allowed when the concentrations are less than: 800ug/day Vit A, 60mg/day Vit C, 10mg/day Vit E and 400ug/day beta-caroteen)
•- use of medication with an effect on the glucose metabolism or inflammation
•- not able to understand the subject information

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