Gastric Cancer Liver Metastasis Cohort of China

Active, not recruiting

• Conditions: Neoplasm Metastasis; Stomach Neoplasms
• Interventions: Procedure: Gastrectomy; Hepatectomy

• Registration Number: NCT04574245
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

This multi-institutional retrospective cohort study aimed to describe and analyze the overall clinical characteristics, therapeutic status and prognosis pattern of gastric cancer liver metastasis (GCLM) in China.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Study First Submitted: 2020-09-23
• Study First Submitted QC: 2020-09-29
• Study First Posted: 2020-10-05
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-03
• Last Update Posted: 2022-10-05
• Primary Completion: 2022-11-30
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Gastric cancer liver metastases cases aged over 18 years old;
• Primary gastric carcinoma (including different histopathological types) confirmed by biopsy or surgery (pre-, intra- or post- treatment);
• In hospital cases between 2020/01/01 to 2019/12/3.

Exclusion Criteria

• Poor compliance to treatment or lost to follow-up;
• Gross loss of clinical data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Resectable group	Gastrectomy; Hepatectomy	-

Primary Outcome Measures

Name	Time	Method
5-year overall survival	2011/01/01-2021/12/31	The proportion (%) of gastric cancer liver metastasis patients that survived beyond five-year follow-up period.
1-year overall survival	2011/01/01-2020/12/31	The proportion (%) of gastric cancer liver metastasis patients that survived beyond one-year follow-up period.
3-year overall survival	2011/01/01-2021/12/31	The proportion (%) of gastric cancer liver metastasis patients that survived beyond three-year follow-up period.

Secondary Outcome Measures

Name	Time	Method
The proportion for synchronous and metachronous liver metastases cases	2010/01/01-2019/12/31	The proportion (%) of synchronous or metachronous gastric cancer liver metastases cases in all gastric cancer cases
The incidence of gastric cancer liver metastasis cases	2010/01/01-2019/12/31	The rate of gastric cancer liver metastasis cases divided by all gastric cancer cases in the study period.
The prognostic predictive value for patients with different C-GCLM classification	2010/01/01-2019/12/31	The proportion (%) of patients of different classification that survived beyond specific follow-up period.
The survival of patients that recieved different therapeutic methods	2010/01/01-2019/12/31	The proportion (%) of patients under different therapies that survived beyond specific follow-up period.

Trial Locations

Locations (1)

General Surgery Institute, China PLA General Hospital; 🇨🇳 Beijing, Beijing, China