Multi-institutional Analysis of Survival and Recurrence Patterns of Different Pathological Regression Types After Neoadjuvant Chemoradiotherapy or Radiotherapy for Esophageal Squamous Cell Carcinoma

Completed

• Conditions: Esophageal Squamous Cell Carcinoma
• Interventions: Other: non-intervention

• Registration Number: NCT06241079
• Lead Sponsor: Tianjin Medical University Cancer Institute and Hospital

Brief Summary

The goal of this multicenter retrospective cohort study is to evaluate the impact of different pathological regression types on survival and recurrence patterns, with a particular focus on ypT0N+ patients in patients with esophageal squamous cell carcinoma. The main questions it aims to answer are the survival and recurrence patterns among the different pathological regression types in patients with esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-03-31
• Primary Completion: 2022-04-28
• Study Completion: 2023-02-01
• Status Verified: 2024-01
• Study First Submitted: 2024-01-18
• Study First Submitted QC: 2024-02-02
• Last Update Submitted: 2024-02-02
• Study First Posted: 2024-02-05
• Last Update Posted: 2024-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 582

Inclusion Criteria

• histologically confirmed potentially resectable ESCC, clinical stage T1-4N0-1M0 (stage I-III) according to the American Joint Committee on Cancer 6th edition staging criteria.

Exclusion Criteria

• incomplete surgical resection, two-dimensional radiotherapy, and incomplete clinical data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ypT+N+	non-intervention	-
ypT0N0	non-intervention	-
ypT0N+	non-intervention	-
ypT+N0	non-intervention	-

Primary Outcome Measures

Name	Time	Method
Overall survival	From date of surgery until the date of death from any cause or last follow-up, assessed up to 10 years.	the time from the date of surgery to death or last follow-up (2023.01.31)