Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Tooth Extraction
- Sponsor
- University of Malaya
- Enrollment
- 10
- Primary Endpoint
- vertical dimension at baseline
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.
Detailed Description
Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.
Investigators
Dr CHEAH CHIA WEI
Principal Investigator
University of Malaya
Eligibility Criteria
Inclusion Criteria
- •maxillary premolar teeth requiring extraction
- •neighboring mesial and distal sound/restored teeth present
- •alveolar bone level (measured from periapical radiographs) more than 50% of the root length
- •age ranges from 25-55 years
Exclusion Criteria
- •bony fenestration of the socket wall confirmed from CBCT scan
- •acute signs of infection
- •periodontally compromised teeth
- •absence of buccal plates
- •any systemic disease which may hinder the healing process
Outcomes
Primary Outcomes
vertical dimension at baseline
Time Frame: before extraction
measurements were done on radiograph (CBCT) images
horizontal dimension at baseline
Time Frame: before extraction
measurements were done on radiograph (CBCT) images
soft tissue level at baseline
Time Frame: before extraction
measurements were done on stone models
volume at baseline
Time Frame: before extraction
measurements were done on radiograph (CBCT) images
Secondary Outcomes
- vertical dimension after extraction(five months after extraction)
- horizontal dimension after extraction(five months after extraction)
- soft tissue level after extraction(five months after extraction)
- volume after extraction(five months after extraction)