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Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

Not Applicable
Completed
Conditions
Tooth Extraction
Registration Number
NCT03851289
Lead Sponsor
University of Malaya
Brief Summary

This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.

Detailed Description

Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
10
Inclusion Criteria
  • maxillary premolar teeth requiring extraction
  • neighboring mesial and distal sound/restored teeth present
  • alveolar bone level (measured from periapical radiographs) more than 50% of the root length
  • age ranges from 25-55 years
Exclusion Criteria
  • bony fenestration of the socket wall confirmed from CBCT scan
  • acute signs of infection
  • periodontally compromised teeth
  • absence of buccal plates
  • any systemic disease which may hinder the healing process

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
vertical dimension at baselinebefore extraction

measurements were done on radiograph (CBCT) images

horizontal dimension at baselinebefore extraction

measurements were done on radiograph (CBCT) images

soft tissue level at baselinebefore extraction

measurements were done on stone models

volume at baselinebefore extraction

measurements were done on radiograph (CBCT) images

Secondary Outcome Measures
NameTimeMethod
soft tissue level after extractionfive months after extraction

measurements were done on stone models

volume after extractionfive months after extraction

measurements were done on radiograph (CBCT) images

vertical dimension after extractionfive months after extraction

measurements were done on radiograph (CBCT) images

horizontal dimension after extractionfive months after extraction

measurements were done on radiograph (CBCT) images

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