Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Retinal Diseases
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Repeatability measurement on volunteers
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Repeatability measurement on volunteers
Time Frame: 2 month
implementing a protocol based on 2 imaging sessions : 1st session with 2 ASL sequences and a 2nd session scheduled 5-7 days later in similar conditions including 1 ASL in volunteers will be applied. This protocol allows assessing the intra-day and the inter-day variability of the measurements using Intra-Class Correlation Coefficient and metric derived from Bland-Altman plots. A total of 20 MRI examinations are planned for this phase of the study.
Secondary Outcomes
- Mesurement of the retinal perfusion by MRI ASL in patient in acute phase(4 years)
- Mesurement of the retinal perfusion by MRI ASLin patient in a chronic phase(4 years)