TherApy in stabLe Coronary Artery dIsease Patients According to Clinical GuideliNes (ALIGN)
- Conditions
- Stable Ischemic Heart Disease
- Registration Number
- NCT04162561
- Lead Sponsor
- National Research Center for Preventive Medicine
- Brief Summary
The aim of this prospective cohort study is to assess the quality of therapy in patients with stable ischemic heart disease (IHD) who had never applied for specialized medical care for the last 3 years and try to accord their treatment with current clinical guidelines.
- Detailed Description
The purpose of this study is to assess the quality of therapy in patients having come for the first time consultation to the specialized cardiology department of the scientific research centre within the PROFILE registry and to try to correct therapy according to current clinical guidelines paying particular attention to reaching target blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), glycosylated haemoglobin - HbA1c (in patients with diabetes mellitus) levels, improving exercise tolerance and quality of life.
The first visit (V0) is an inclusion in the study. During this visit, an attempt to correct or start (if it had not been started before) antiplatelet, hypolipidemic, antihypertensive and antianginal therapy will be made.
The second visit (V1) is planned for each patient three months after the first visit (V0). During the second visit number of patients who reached target levels of BP, LDL-C, frequency of angina attacks will be assessed. If necessary, correction of therapy will also be made.
The third visit (V2) is planned for each patient one year after the first visit (V0). During the third visit reaching target BP, LDL-C levels, frequency of angina attacks will be assessed. If necessary, therapy correction will be recommended.
The last visit - telephone contact with patients - is expected in 2 years after the first visit. During that visit it is planned to assess life status, complications and current medical treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 70
All patients with documented IHD having consequentially come for the first time for consultation to the specialized cardiology department of the scientific research center from December 31, 2017 to December 31, 2022.
Documented IHD:
-
Positive results of the angina questionnaire (typical angina)
-
Positive exercise electrocardiography or stress echocardiography, plus one of the following criteria:
- ischemia documented by scintigraphy study
- invasive coronary angiography data (stenosis of at least 75% in at least one main coronary artery)
- previous coronary revascularization (percutaneous coronary intervention (PCI), coronary artery bypass graft surgery (CABG))
- previous myocardial infarction
- patients who had elective PCI or CABG
- Patients with acute IHD (less than 30 days since the last ischemic event with or without invasive procedures for the treatment of the event)
- Patients' refuse to follow the study's graphic of doctors' visits
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Achievement of the target LDL-C and BP levels 1 year Target LDL-C levels - less than 1.8 mmol/l, target BP levels - less than 140/90 mmHg
Adherence to life-modifying treatment 1 year The Adherence scale of the Russian National Society of evidence based pharmacotherapy modified for patients with coronary heart disease will be used to assess patients' adherence to treatment. The patients will be asked questions about taking prescribed medications as recommended by a doctor.
The score system with the min value in the scale 0 and the max value 4 is used for the assessment of the results: 0 - adherent, 1-2 - partially adherent, 3 - partially non-adherent, 4 - non adherent.
- Secondary Outcome Measures
Name Time Method Stroke 2 years description - the total number of events
Myocardial revascularization 2 years description - the total number of events
Unplanned hospitalization for cardiovascular diseases 2 years description - the total number of events
all-cause mortality 2 years improvement of the functional class of angina in at least 1-grade level 1 year Assessment of the functional class of angina will be made according to the Canadian Cardiovascular Society grading of angina pectoris
Myocardial Infarction 2 years description - the total number of events
Compliance to life-modifying treatment 1 year Necessity of the use of the following drugs will be investigated for each patient: antiplatelets, anticoagulants, hypolipidemic drugs, beta-blockers, ACE-inhibitors/ARBs.
Later, percent of the drugs that each patient actually takes will be calculated (for example, three drugs are indicated and two are taken - (2/3)\*100 = 66.6%).
In the end, the mean adherence to therapy in the investigated group will be calculated.
Trial Locations
- Locations (1)
National Research Center for Preventive Medicine
🇷🇺Moscow, Russian Federation