Retrospective Descriptive Study of Platelet Transfusion in Patients With Palliative Hematologic Malignancies at the University Hospital of Besançon

Completed

• Conditions: Palliative Care; Platelet Transfusion
• Interventions: Other: descriptive

• Registration Number: NCT03814486
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its treatments. Yet, a few studies was interested in, whereas platelet transfusion is the only treatment indicated. As it represent a scarce, limited resource, the ethical principles are in conflict in this setting.

The purpose of this study was to describe retrospectively platelet transfusion in the six last few month of life of patients with hematologic malignancies at the CHU of Besançon (France) between 01/07/15 and 31/12/16.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-01
• Primary Completion: 2018-07-01
• Study Completion: 2018-07-01
• Status Verified: 2018-12
• Study First Submitted: 2019-01-02
• Study First Submitted QC: 2019-01-22
• Study First Posted: 2019-01-24
• Last Update Submitted: 2019-01-28
• Last Update Posted: 2019-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 119

Inclusion Criteria

• patient with hematological malignancies
• transfused in platelet at least once in the last 6 months of life
• hospitalised or follow up at the CHU of Besancon at least once
• dead during the period of the study

Exclusion Criteria

• patient with other oncologic malignancies
• not transfused in platelet in the last 6 months of life
• never hospitalised or follow up at the CHU of Besancon
• alive

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patient transfused in platelet in the 6 last months of life	descriptive	patient with hematological malignancies follow or hospitalised at least once in CHU of Besancon died in the period of the study transfused at least once in the 6 months of life

Primary Outcome Measures

Name	Time	Method
evaluate frequency of platelet transfusion at the end of life	18 months (between 07/01/2015 and 12/31/2016)	to calculate the number of platelet transfusion at the end of life. The number of platelet transfusion between 6 months and death are collected in each periods of 2 weeks to calculate the number of transfusion per patient during each 2 weeks.
evaluate efficacy of prophylactic platelet transfusion at the end of life	18 months (between 07/01/2015 and 12/31/2016)	to calculate the platelet yield in percentage
evaluate efficacy of non prophylactic platelet transfusion at the end of life	18 month (between 07/01/2015 and 12/31/2016)	to calculate the transfusional interval between 2 platelet transfusion in days

Secondary Outcome Measures

Name	Time	Method
demographic characteristic	18 months (between 07/01/2015 and 12/31/2016)	characteristic of patient (age, diagnosis,location of death, palliative care received...)

Trial Locations

Locations (1)

Moracchini; 🇫🇷 Besançon, France