effect of two drugs (ketamine or dexmedetomidine) on motor evoked potential used to monitor spinal cord function during spine surgery

Not Applicable

Conditions: Health Condition 1: M958- Other specified acquired deformities of musculoskeletal system

Registration Number: CTRI/2019/08/020645

Lead Sponsor: department of anaesthesiology and critical care

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

2.ASA- I and III

3.Patients undergoing spine surgery ( intraspinal tumors, tethered spinal cord, spinal cord stenosis, fracture of the vertebral body, scoliosis correction, ossification of the posterior spinal ligament ) with TceMEP monitoring

4.Patients with bilateral upper and lower limb motor function >=4/5 grade of Medical Research Council (MRC) Scale

Exclusion Criteria

1.severe cardiovascular diseases (such as heart block, heart failure, left ventricular dysfunction)

2. significant pulmonary, renal, hepatic or neuromuscular disease,

3.contraindications for MEP monitoring such as epilepsy, cortical lesion, raised intracranial tension, cardiac diseases, intracranial electrodes, vascular clips/shunts,

4. history of chronic alcohol use

5.Anaemia , Hb <= 10gm/dl

6.defined allergy to any of study drugs

7.BMI >30 kg/m2

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To assess the effect of ketamine and dexmedetomidine infusion on amplitude of MEP <br/ ><br>2.To assess the effect of ketamine and dexmedetomidine infusion on latency of MEP <br/ ><br>Timepoint: intraoperative period at 30 minutes interval and at the end of surgical intervention

Secondary Outcome Measures

Name	Time	Method
1.Changes in perioperative hemodynamic parameters <br/ ><br>2.Dosage of propofol used <br/ ><br>3.Total opoids requirement in intraoperative period <br/ ><br>4.Effect on extubation parameter in term of Emergence and extubation time <br/ ><br>5.Pain assessment in postoperative period and postoperative analgesic requirement for 1st 24 hours <br/ ><br>6.Post operative complications if any <br/ ><br>Timepoint: in intraoperative and postoperative period