Functional Respiratory Imaging of Airways in ARDS

Not Applicable

Completed

• Conditions: ARDS, Human
• Interventions: Procedure: Repeated CT scan; Device: CT scan

• Registration Number: NCT03309085
• Lead Sponsor: University Hospital, Antwerp

Brief Summary

This is a prospective single-center cohort trial to compare regional bronchial recruitment, bronchial distention and alveolar recruitment in 6 patients with acute respiratory distress syndrome (ARDS). The investigators used CT scan images as the imaging modality, and the subjects were scanned on end-expiratory lung volume with different positive end-expiratory pressures. Those images were post-processed to evaluate the airways.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08-13
• Primary Completion: 2014-04-14
• Study Completion: 2014-04-14
• Status Verified: 2017-10
• Study First Submitted: 2017-10-03
• Study First Submitted QC: 2017-10-12
• Last Update Submitted: 2017-10-12
• Study First Posted: 2017-10-13
• Last Update Posted: 2017-10-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• mechanically ventilated
• moderate or severe ARDS, as defined by the Berlin criteria

Exclusion Criteria

• pregnancy
• hemodynamic instability
• obesity (BMI >30)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Single arm	Repeated CT scan	Repeated CT scan
Single arm	CT scan	Repeated CT scan

Primary Outcome Measures

Name	Time	Method
Regional bronchial recruitment	Through study completion, within 24 hours after inclusion	The difference in bronchial tree volume increase from one PEEP level to the other
Regional bronchial dilation	Through study completion, within 24 hours after inclusion	The difference in bronchial diameter from one PEEP level to the other
Regional alveolar recruitment	Through study completion, within 24 hours after inclusion	The difference in alveolar volume from one PEEP level to the other

Secondary Outcome Measures

Name	Time	Method
Correlation between parenchymal recruitment and bronchial recruitment	Through study completion, within 24 hours after inclusion	Correlation between parenchymal recruitment (in milliliter) and bronchial (in milliliter) recruitment for each type of ARDS (focal versus diffuse)

Trial Locations

Locations (1)

Antwerp University Hospital; 🇧🇪 Edegem, Antwerp, Belgium