Cognitive and mood effects of a dietary supplement containing probiotics, vitamins and zinc: a randomized, double-blind, placebo-controlled crossover study in healthy humans.

Completed

• Conditions: Mild/moderate stress level; mood and cognitive functions; Neurological disorders

• Registration Number: NL-OMON51267
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 44

Inclusion Criteria

* 18-60 years old
* BMI in healthy range (18.5-25 Kg/m2)
* Score of mild/moderate stress level on DASS-42 (Depression, Anxiety and
Stress Scale)
* Available for study visits

Exclusion Criteria

- Type 1 diabetes (one of the main metabolites of Lactobacillus is acetic acid.
In animal studies, acetic acid has been reported to increase liver lipid
metabolism and fat digestion
affects the pancreas, and this has also been used in studies on obesity)
- Currently using any medication or dietary supplements that can
interfere with the research, or the interpretation of the research results,
such as: melatonin, vitamin E, multivitamins,
vitamin B complex, ginkgo Bilbao, fish oil or other cognitive enhancing
nutritional or
herbal supplements.
- Daily concentrated sources of probiotics than the research products provided
(eg probiotic / prebiotic tablets, capsules, powders,).
- Taking any medication at this time or in the 4 weeks prior to the first day
of study that would interfere with the purpose of the study, such as
psychoactive drugs (anxiolytics, sedatives, hypnotics, antipsychotics,
antidepressants, anticonvulsants, centrally acting corticosteroids, opioid
painkillers))
Excessive caffeine intake (> 500 mg per day, approximately the amount of
caffeine in 5 cups of brewed coffee)
- Excessive alcohol consumption (corresponding to the man drinking more than 21
units / week and for the woman more than 14 units / week) for 2 weeks prior to
screening and during the intervention period
- Recent (offer for screening in the last 4 weeks) of ongoing antibiotic
therapy during the intervention period
- History of self-reported dementia, stroke and other neurological conditions
- Being an employee of Wageningen University, division Human Nutrition and
Health and Food quality and design

Study & Design

• Study Type: Interventional
• Study Design: Not specified