Cognitive effects of nutritional manipulation using the amino acid tyrosine in healthy subjects with ADHD-symptoms

Recruiting

• Conditions: ADHD; attention deficit disorder; 10009841

• Registration Number: NL-OMON43441
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 26

Inclusion Criteria

Between 18 and 35 years of age;
Willingness to sign an informed consent;
Showing ADHD symptoms, but not sufficient for the diagnosis;
BMI of 18.5-30.

Exclusion Criteria

Use of recreational drugs in the past month;
Excessive drinking;
Pregnancy;
Use of ADHD medication in the past;
Allergy for tyrosine containing substances;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the number of Commission errors derived from the<br /><br>continuous performance test (CPT). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The following secondary parameters will be tested in this study:<br /><br>* performance on the stop-signal task as a measure of motor inhibition;<br /><br>* performance on the verbal learning task as a measure for working memory and<br /><br>long-term memory;<br /><br>* the task-switching task as a measure to assess switching attention;<br /><br>* the Profile of Mood States and Bond & Lader as measures of mood and perceived<br /><br>alertness;<br /><br>* blood biomarkers, from which the amount of tyrosine and prolactine will be<br /><br>analysed, as measure of the association between amount of uptake and cognitive<br /><br>performance.</p><br>