Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Phase 2

Completed

• Conditions: Contrast Induced Nephropathy
• Interventions: Drug: sodium bicarbonate; Drug: Acetazolamide; Drug: normal salin

• Registration Number: NCT00634491
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Detailed Description

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Study Timeline

• Study Start: 2007-09
• Primary Completion: 2008-02
• Study Completion: 2008-02
• Study First Submitted: 2008-02-14
• Status Verified: 2008-03
• Study First Submitted QC: 2008-03-04
• Last Update Submitted: 2008-03-04
• Study First Posted: 2008-03-13
• Last Update Posted: 2008-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

• patient that underwent coronary angiography

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Exclusion Criteria

• serum Cr. more than 3 mg/dl
• electrolyte and acid-base imbalance
• pulmonary edema
• allergy to Acetazolamide

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	sodium bicarbonate	150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography
2	Acetazolamide	Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography
3	normal salin	normal salin 1cc/kg/hr before and after angiography

Primary Outcome Measures

Name	Time	Method
Increased base line creatinine at least 25%	24 hr later

Trial Locations

Locations (1)

Fars Heart Foundation , Kowsar hospital; 🇮🇷 Shiraz, Iran, Islamic Republic of