DRKS00028279招募中不适用
Research into the causes, diagnostics and course of diseases of the autonomic nervous system
niklinik RWTH AachenKlinik für Neurologie0 个研究点目标入组 20 人开始时间: 2022年3月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 60 Years（—）
- 性别
- All
入选标准
- •1. age between 18 - 60 years (register: at least 18 years old).
- •2. written declaration of consent
- •3. persons who are legally competent and mentally capable of
- •to follow the instructions of the study personnel
- •4. healthy persons
- •Patients with POTS, hypermobile or classic EDS,
- •SFN or PAF/AAN
- •(Diagnosis made in the ANS outpatient clinic on the basis of the
- •clinical examinations including autonomic
- •function testing and skin biopsy)
- •Exclusion of other causes (including by means of
- •cranial MRI and basic laboratory).
- •5. in all POTS, EDS and PAF/AAN patients at least the following examinations have been performed in clinical routine in the last 6 months before inclusion in the ProANS study or will be completed otherwise
- •completed (will not be added to the registry!)
- •- Quantitative sensory testing (QST)
- •- skin biopsy
- •- Blood sampling (noradrenaline, adrenaline and specific
- •antibodies)
- •- Tilt table (KT) incl. heart rate analysis
- •- Quantitative sensorimotor axon reflex testing
排除标准
- •1. pregnancy (anamnestic, not in the register)
- •2. minority
- •3. pacemaker (HSM) or deep brain stimulation (TSH)
- •(exclusion for electrophysiological examinations)
- •(not in the registry)
- •4. moderate and severe sensorimotor
- •polyneuropathy (not in the registry)
- •5. other neurodegenerative diseases such as Parkinson's,
- •Alzheimer's disease or inflammatory diseases such as multiple
- •sclerosis (not in the registry)
- •6. severe heart failure (not in registry)
- •7. diabetic rentinopathy (exclusion for Valsalva
- •maneuvers, not in registry)
- •8. poorly controlled diabetes mellitus (not in the registry)
- •9.drug use (not in the register)
- •10.persons who are institutionalized by official or judicial order
- •are placed in an institution
- •- Claustrophobia
- •- Metal implants, active medical implants (e.g.
- •Infusion pump, etc.), or other conditions that preclude an MRI examination
研究者
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