Parecoxib, celecoxib and paracetamol for pain management following caesarean delivery

Phase 4

Completed

• Conditions: Pain relief after caesarean delivery; Reproductive Health and Childbirth - Childbirth and postnatal care; Anaesthesiology - Pain management

• Registration Number: ACTRN12609001041246
• Lead Sponsor: King Edward Memorial Hospital for Women

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-12-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

Elective caesarean section under combined spinal epidural anaesthesia
American Society of Anesthesiologists classification 1 or 2

Exclusion Criteria

Pre-operative use of opioid medication
Contraindication to combined spinal epidural anaesthesia
Contraindication to parecoxib, celecoxib, paracetamol or tramadol
Known intolerance or allergy to oxycodone, morphine, parecoxib, celecoxib or sulphonamides
Pre-operative pruritus or nausea
Failure to identify the subarachnoid space or to catheterise the epidural space at the time of combined spinal epidural anaesthesia
Inadvertent dural puncture with the epidural needle or catheter
Requirement for intra-operative opioid or epidural analgesics other than local anaesthetic
Conversion to general anaesthesia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Epidural pethidine consumption in the first 24 hours postoperatively[0 to 24 hours post-operatively]

Secondary Outcome Measures

Name	Time	Method
Efficacy of the analgesic regimen determined by the area under the curve for rest and dynamic (movement-induced) pain scores in the first 24 hours postoperatievly[24 hours post-operatively: at 6, 12 & 24 hours];Efficacy of the analgesic regimen determined by the pain scores at rest and with movement[6,12 and 24 hours post-operatively];Incidence of analgesic supplementation with oral tramadol[to 24 hours post-operatively (the starting or '0' timepoint is the end of surgery)];Maternal satisfaction with analgesic regimen. This will be assessed using a 0-10 numerical rating score, a satisfaction rating of excellent/good/fair/poor and free comments[48 hours post-operatively]