Does methylnaltrexone reduce the incidence and severity of itch following spinal anaesthesia with intrathecal morphine in women undergoing caesarean delivery.

Phase 4

Completed

• Conditions: Incidence and severity of pruritus after intrathecal morphine at caesarean delivery; Anaesthesiology - Other anaesthesiology; Reproductive Health and Childbirth - Childbirth and postnatal care

• Registration Number: ACTRN12612000572864
• Lead Sponsor: King Edward Memorial Hospital for Women

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-28
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 130

Inclusion Criteria

1. American Society of Anesthesiologists classification 1 or 2
2. Elective caesarean section under spinal anaesthesia, with or without epidural catheterization

Exclusion Criteria

1. Preoperative use of opioid medication
2. Contraindication to spinal anaesthesia
3. Preoperative pruritus for any reason
4. Weight outside the range 62-114 kg
5. Severe renal impairment, gastro-intestinal disease or diarrhoea
6. Conversion to another method of anaesthesia, prior to study drug, for any reason
7. Failure to administer intrathecal morphine
8. Administration of a drug with anti-pruritic activity (propofol, antihistamine, 5HT3-receptor antagonists or other drugs with opioid agonist or antagonist activity such as tramadol or naloxone) prior to study drug
9. Administration of epidural opioid prior to administration of study drug.

Study & Design

• Study Type: Interventional
• Study Design: Not specified