Serum Inflammatory Marker in Patients With Diagnosis of Nontuberculous Mycobacterial Pulmonary Infection

Completed

• Conditions: Nontuberculous Mycobacterial Pulmonary Infection

• Registration Number: NCT00942916
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

This study is for those who had nontuberculous mycobacterial pulmonary infection with higher a serum inflammatory marker than those who had colonization.

Detailed Description

Nontuberculous mycobacteria (NTM), not like Mycobacterium tuberculosis, is ubiquitous in environment including soil and water. Therefore, NTM pulmonary infection is not diagnosed only by microbiology of respiratory specimen but also clinical and radiographical findings.(1) Due to airway NTM colonization is not uncommon in sputum, diagnosis of pulmonary NTM infection is a big challenge in clinical practice. Especially NTM burden is increasing in recent literature.(2,3) Besides, the short-term mortality is reported higher in patients with NTM infection in medical ICU by Shu et al.(4) Early diagnosis and then treatment of NTM infection become important though NTM infection is considered as indolent process before.(1) Inflammatory marker in the patients with NTM being isolated from respiratory specimens is an indicator for differentiating true infection from colonization.(5,6) Those inflammatory factors might include blood white count, C-reactive protein, cytokines, procalcitonin , trigger receptor expressed on myeloid cell-1 (TREM-1) and Toll-like receptor-2. We therefore conduct this prospective study for analyzing

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-07-19
• Study First Submitted QC: 2009-07-20
• Study First Posted: 2009-07-21
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2012-06
• Last Update Submitted: 2012-08-28
• Last Update Posted: 2012-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• more than 18 years
• study group : Satisfied the criteria for NTM pulmonary disease according to the ATS diagnosis guidelines.
• control groups: they had positive sputum culture for NTM but not fulfilled the diagnosis criteria

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Exclusion Criteria

• Those with bleeding tendency
• No inform consent
• Female with pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis of NTM pulmonary disease according to the ATS guidelines	2 year

Secondary Outcome Measures

Name	Time	Method
mortality	2 year

Trial Locations

Locations (1)

National Taiwan University Hospital, Yun-Lin Branch; 🇨🇳 Yun-Lin County, Taiwan