Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3

Not Applicable

Recruiting

• Conditions: Myocardial Infarction with Nonobstructive Coronary Arteries
• Interventions: Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

• Registration Number: NCT05426408
• Lead Sponsor: Karolinska Institutet

Brief Summary

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-06-10
• Study First Submitted QC: 2022-06-16
• Study First Posted: 2022-06-22
• Study Start: 2022-11-01
• Status Verified: 2024-10
• Last Update Submitted: 2025-03-06
• Last Update Posted: 2025-03-10
• Primary Completion: 2025-12-31
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
• age 35-80 years
• reading and writing proficiency in Swedish

Exclusion Criteria

• Claustrofobia
• Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
• Asthma or severe chronic obstructive lung disease
• eGFR < 30 ml/min
• spontaneous coronary artery dissection
• acute pulmonary embolism
• acute myocardial infarction type 2
• cardiomyopathy other than takotsubo syndrome
• a previous myocardial infarction due to CAD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with MINOCA undergoing CMR	Cardiac magnetic resonance imaging to study coronary microvascular dysfunction	Patients will be their own controls

Primary Outcome Measures

Name	Time	Method
Diagnostic yield	Through investigation completion, usually 2 hours	To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis

Secondary Outcome Measures

Name	Time	Method
Prevalence of CMD in different final MINOCA diagnoses	Through investigation completion, usually 2 hours	To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group
Prevalence of CMD in MINOCA	Through investigation completion, usually 2 hours	To determine the proportion of patients with the working diagnosis of MINOCA who have CMD.
Angina pectoris	3 Months	To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD

Trial Locations

Locations (1)

Per Tornvall; 🇸🇪 Stockholm, Sweden