Identification of miRNA relevant for diagnosis and prognosis of oral squamous cell carcinoma patients

Recruiting

• Conditions: C01; C02; C03; C04; C05; C06; Malignant neoplasm of base of tongue; Malignant neoplasm of other and unspecified parts of tongue; Malignant neoplasm of gum; Malignant neoplasm of floor of mouth

• Registration Number: DRKS00012892
• Lead Sponsor: niklinik Köln-Abteilung für Mund-, Kiefer- und plastische Gesichtschirurgie-

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Written informed consent
- Indication for surgical treatment of head and neck malignoma in accordance with local tumorboard vote.

Exclusion Criteria

- Pregnancy
- Patients < 18 years
- Patients who are unable to give informed consent due to their dependence on alcohol, drugs or mind-altering medication
- Patients who are unable to give informed consent due to their psychiatric disorder
- Patients who are unable to give informed consent due to any kind of medical, psychological or other personal disorder

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MicroRNA are obtained from patients' tissue and blood samples. Analysis of micrcoRNA expression profiles from diverse pTNM stages. Can certain expression profiles indicate early metastatic spread or rapid tumor progression? Expression profiles of all enrolled patients are analyzed after 2 years of clinical trial, preliminary results are assessed biannually.

Secondary Outcome Measures

Name	Time	Method
Analysis of micrcoRNA expression profiles from pT1,2 OSCC (oral squamous cell carcinoma) with/without metastatic spread. Are indicators for early metastatic spread detectable?