COVID-19 Infection and Idiopathic Membranous Nephropathy
- Conditions
- Idiopathic Membranous Nephropathy
- Registration Number
- NCT05691179
- Lead Sponsor
- Beijing Friendship Hospital
- Brief Summary
Infection is one of common risk factors for relapsing of idiopathic membranous nephropathy (IMN). However, it is still unclear wheather COVID-19 infection can induce the relapsing of IMN. Herein, in this prospective, multi-center, cohort study, the investigator enrolled the IMN patients with COVID-19 infection.
All subjects will be followed for three months with four visits at 1, 2 and 3 months. Then the investigator will compare the rate of replase of IMN in the two groups to evaluate the association of COVID-19 infection and replapse of IMN.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 130
- the status of nephrotic syndrome is complete remmision or partial remmision;
- estimated glomerular filtration rate (eGFR according to the CKD-EPI formula) ≥60 mL/min per 1.73 m2;
- patients with a moderate risk of IMN.
- secondary causes of MN;
- the labarotary data two months before enrolement is absent.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method primary outcome 3 months relaspe of nephrotic syndrome: proteinuria\<0.3g/d, serum albumin\>30g/l, serum creatitine below 111 μmol/l
- Secondary Outcome Measures
Name Time Method secondary outcome 0.5, 1, and 2 months relaspe of nephrotic syndrome: proteinuria\<3.5g/d (decreased over 50% of baseline), serum albumin\>30g/l, steady serum creatitine (fluctuated less than 20% of baseline), meet the above criteria over 2 times
Trial Locations
- Locations (3)
Beijing Pinggu Hospital
🇨🇳Beijing, Beijing, China
Beijing Friedship Hospital
🇨🇳Beijing, Beijing, China
Beijing Liangxiang Hospital
🇨🇳Beijing, Beijing, China