Effect of a bundle of non-pharmacological interventions on the stress response to surgery

Phase 4

• Conditions: perioperative stress; surgical stress; 10027655; 10043413

• Registration Number: NL-OMON53770
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

- 18 years or older
- ASA I-III
- Ability to give oral and written informed consent
- Scheduled to undergo elective surgery with an expected minimum duration of
120 minutes
- Scheduled to undergo intermediate to major risk surgery

Exclusion Criteria

- Day case surgery
- Use of neuraxial anaesthetic technique
- Chronic use of steroids
- Indication for peri-operative steroids (e.g. COPD, adrenal insufficiency)
- Bronchial hyperreactivity
- Unable to give written or oral informed consent
- Patient refusal
- Planned for post-operative ICU admission
- ASA >= 4
- Scheduled for minor risk surgery (Levels of Surgical Complexity 1 and 2)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Serum cortisol levels on the first postoperative day. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary endpoints are IL-6, NLR, CRP and glucose on postoperative day 1. </p><br>