A Comparative Study Of Using Tranexamic Acid Versus Botropase Reducing postoperative Bleeding And seroma Formation Following Modified Radical Mastectomy

The patients who meet the inclusion criteria will be included in the study and will receive Inj.Tranexamic acid first dose (1gm IV in 100ml Normal Saline) initially at the the time of induction of anesthesia, followed by oral tab Tranexamic acid 500mg 8 hourly for 5 days from POD1. These patients will be labelled as Group A and will be operated in the same unit in the surgery department. Breast cancer patients who are operated in other units in the department will receive Inj.botropase 2ml intravenously at the time of induction of anesthesia and followed by 2 ml intra venously 12 hourly for 5 days and will be labelled as group B. Demographic data and following data will be collected and will be analysed for the following parameters. 1 Post operative bleeding-will be measured clinically through drain placed intraoperatively or by USG guidance if needed. 2 Seroma formation- will be measured clinically through the intraoperative drain and through USG if needed. 3 Postoperative wound healing time-will be calculated from POD 1 and we will count the number of days the wound takes to heal completely and it will be assessed clinically. 4 Postoperative hospital stay- we will count the number of days the patient takes to get discharged. 5 Post operative wound infection – wound infection will be assessed by clinical symptoms like fever, pain, discharge and signs like erythema, local rise of temperature, tenderness and discharge from the wound. 6 Demography and spectrum of patients