To compare the doses of tranexamic acid for maximum reduction in perioperative blood loss in abdominal oncosurgeries( A Randomized Trial)
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To find the maximum decrease in perioperative blood loss using two different dosing regimens of tranexamic acid.
研究概览
简要总结
We planned to study the dosing regimens of Tranexamic acid required to reduce perioperative blood loss in abdominal oncosurgeries as optimum dose and administration schedules of tranexamic acid is still subject of research, aiming at safe inhibition of fibrinolysis in the perioperative period. This study will help in finding the dose of tranexamic acid for maximum reduction in blood loss and will also reduce the transfusion requirements and transfusion related reactions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I,II,III Age between 25 years-75 years undergoing abdominal oncosurgeries.
排除标准
- •Refusal to participate in study Contraindication to the drug ASA IV,V,VI patients.
结局指标
主要结局
To find the maximum decrease in perioperative blood loss using two different dosing regimens of tranexamic acid.
时间窗: To find the maximum decrease in perioperative blood loss using two different dosing regimens of tranexamic acid by assessing blood loss at the end of surgery, 12, 48 hours after surgery and patients hemoglobin @ 6, 12, 24 hours after surgery
次要结局
- (i)To compare two dosing regimens of tranexamic acid in terms of perioperative blood transfusion requirements and in first 48 hours.((ii)To compare in terms of post op Hb level at 12, 24 and 48 hours post tranexamic acid bolus and infusion doses respectively)
研究者
Shristi Shikha
Indira Gandhi Medical College,Shimla