To see the effect of resveratrol and copper on outcome of death in patients with blood cancer admitted to Intensive Care Unit with fever and infection.
- Conditions
- Health Condition 1: C81-C96- Malignant neoplasms of lymphoid, hematopoietic and related tissue
- Registration Number
- CTRI/2020/03/024286
- Lead Sponsor
- TRAC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Age 18 -70 years
2. Hemato-lymphoid malignancy
3. Febrile neutropenia with expected duration of neutropenia >7 days
4. Need of ICU admission
1.History of Resveratrol and/or copper intake in dietary supplements in last 3 week
2.Patient admitted after cardiopulmonary resuscitation
3.Patients on warfarin
4.Underlying advance malignancy with no treatment option
5.Chronic renal failure with GFR <30 ml/min
6.Chronic liver dysfunction/cirrhosis
7.Pregnancy (urinary pregnancy kit for females of reproductive age group)
8.Known case of HIV/AIDS.
9.Moribund patient unlikely to survive for >48 hours at the time of screening as judged by the treating intensivist based on the presence of severe multi-organ dysfunction and shock despite resuscitation at the time of screening as assessed by any of the following parameters (not limited to):
ï?¯ Inability to maintain MAP >65 mm Hg on doses of noradrenaline or adrenaline exceeding 0.66 mic/kg/min or
ï?¯ Inability to maintain MAP >65 mm Hg on combination of vasopressin with either noradrenaline or adrenaline
ï?¯ Severe lactic acidosis (pH <7.15, lactate >8 mmol/L) in spite of fluid resuscitation, vasopressors and ventilator support.
ï?¯ The ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2 to FiO2 or PF ratio) <= 100.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method