NCT00443144已完成不适用
D3-Growth Hormone Receptor Polymorphism and Total Effect of Recombinant Human Growth Hormone on Growth in Girls With Turner Syndrome
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 1
研究概览
简要总结
The protein polymorphism of the growth hormone receptor characterized by the genomic deletion of exon 3 has been linked to the magnitude of the first-year-growth response to growth hormone (GH) in girls with Turner syndrome.
Objective: to study the long-term effect of GH therapy in Turner syndrome in correlation to this GHR polymorphism in a mainly retrospective design (chart-review).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 38 Months 至 14 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Turner syndrome defined by a structural aberration or lack of the X chromosome.
- •Growth velocity less than 2 cm/year at the time of final analysis (= final height).
排除标准
- •Age <3.5 or >14 years at start of GH therapy,
- •GH peak serum levels < 8 ng/ml in two independent tests,
- •Thelarche at start or during the first year of treatment,
- •Oxandrolone therapy for any time and a duration of GH therapy less than 2 years.
研究者
Gerhard Binder
Pediatric Endocrinology
University Hospital Tuebingen
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
GH receptor polymorfism: the effects on growth hormone substitution in patients with growth hormone deficiencyNL-OMON30312eids Universitair Medisch Centrum200
已完成
不适用
Molecular Basis of the Growth Axis in Short StatureGrowth Hormone DeficiencyNCT00453245HaEmek Medical Center, Israel
已完成
不适用
NGS Genome Analysis in Personalisation of Lung Cancer TreatmentLung CancerNCT02281214Centre Georges Francois Leclerc165
已完成
不适用
Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaNCT01255150National Cancer Institute (NCI)15
Unknown
不适用
Genetics Study of In-stent RestenosisCoronary Artery DiseaseNCT01670396Shanghai Zhongshan Hospital300