A COMPARATIVE STUDY OF PREOPERATIVE VERSUS POSTOPERATIVE ADMINISTRATION OF 120 mg ETORICOXIBS IN MANDIBULAR THIRD MOLAR SURGERY: A RANDOMIZED SPLIT-MOUTH DOUBLE-BLINDED CLINICAL TRIA

Completed

• Conditions: Does preoperative administration of Etoricoxib 120 mg have the higher efficacy in reduction of postoperative pain in mandibular third molar surgery compared to postoperative administration of the same drug?; Analgesia; Etoricoxib; preoperative; third molar surgery; postoperative complication

• Registration Number: TCTR20210726002
• Lead Sponsor: Department of Oral and Maxillofacial Surgery, Floor 13, faculty of Dentistry, Mahidol university

Brief Summary

Preoperative administration of Etoricoxib 120 mg revealed significant average pain reduction when compared to the same amount of drug administered postoperatively after four hours of local anesthesia deposition in mandibular third molar surgery. The mean rescue analgesic requirement was not statistically significant between both groups in postoperative evaluation period.

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-01-01
• Study Start: 2021-07-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

1. American Society of Anesthesiologists ASA : class I or II
2. Patients with presence of asymptomatic, bilaterally similar partially or totally impacted lower third molars as classified by the inclination according to the Winter classification, class and position according to the Pell and Gregory classification that requires flap opening, bone removal, and tooth separation during the operation
3. Age 18 to 30 years

Exclusion Criteria

1. Patients with any history of allergy to non-steroidal anti-inflammatory drugs
2. Presence of systemic disease that contraindicates the surgical procedure such as uncontrolled hypertension, uncontrolled diabetes, asthma, and any pathological disease
3. Pre-existing acute infection and inflammation
4. Patients with a history of narcotic or alcohol abuse
5. Chronic opioid analgesic use
6. Pregnancy and lactating mother
7. The surgical time exceeding 120 minutes or any surgical complications occurred that would render the procedures non-comparable
8. Unable to follow the instructions or refusal to the follow-up appointments

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of postoperative pain 6 months Numerical rating scale (NRS)

Secondary Outcome Measures

Name	Time	Method
Comparison of total rescue analgesic requirement 6 months Total rescue analgesic requirement