Effect of Rapeseed Oil and Sunflower Oil
Not Applicable
- Conditions
- Familial Hypercholesterolemia
- Interventions
- Dietary Supplement: rapeseed oilDietary Supplement: sunflower oil
- Registration Number
- NCT00924274
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Familial hypercholesterolemia (FH), an inherited disorder of lipoprotein metabolism, is a risk for early cardiovascular disease (CVD). This autosomal dominant disease is characterized by markedly elevated plasma concentrations of low density lipoprotein (LDL) and total cholesterol (TC). The purpose of this study is to compare the effect of a diet low in saturated fats but enriched either with rapeseed oil (RO) or sunflower oil (SO) in children and adolescents with FH on serum lipoproteins.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- chilren and adolescents between 6 and 18 years of age
- LDLc > 130 mg/dl and
- TC > 200 mg/dl
- 7 day nutrition record
- written informed consent
Exclusion Criteria
- overweight
- underweight
- mental disability
- drug therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Lifestyle counseling rapeseed oil - sunflower oil sunflower oil -
- Primary Outcome Measures
Name Time Method Blood analysis including fasting serum lipoproteins (TC, LDLc; HDLc; TG, Lp(a), Apolipoprotein A-1, Apolipoprotein B, BB, hs-CRP, GOT, GPT, GGT, acid composition of plasma lipids. done in Week 1, Week 7, Week 13
- Secondary Outcome Measures
Name Time Method Motivation, compliance, increase of quality of life. done in Week 1 and Week 13 Acceptance and approach to the disease. done in Week 1 and Week 13 Improvement of knowledge and understanding about the disease by the patients. done in Week 1 and Week 13
Trial Locations
- Locations (1)
Division of Nutrition and Metabolism, Department of Pediatrics, Medical University of Vienna
🇦🇹Vienna, Austria