T-cell turnover during HIV infection; production and life span of T-cells in HIV infected individuals during cART - T-cell turnover during HAART: the CTRL-ALT-DEL study

niversitair Medisch Centrum Utrecht0 个研究点目标入组 25 人开始时间: 待定最近更新: 2024年8月12日

适应症

试验速览

暂无简介。

•All groups:
•-All study subjects have to be adults (18 years of age, or older) and sound of mind and judgement.
•Study group:
•-They have to be HIV-1 infected and treated with cART.
•-They have to have a long-term undetectable viral load (= HIV RNA , 50 copies/ml blood)
•-The number of CD4 T-cells should have increased to at least 350 cells per microliter blood.
•Control group low CD4 T-cells during cART:
•-They have to be HIV-1 infected and treated with cART.
•-They have to have a long-term undetectable viral load (= HIV RNA , 50 copies/ml blood)
•-The number of CD4 T-cells should be less than 350 cells per microliter blood.
•Control group HIV-1 infected, high CD4 T-cell numbers without cART
•-They have to be HIV-1 infected.
•-The number of CD4 T-cells should be more than 350 cells per microliter blood.

•-HIV-2 infection
•-Participants may nog have an active infection for which anti microbial drugs are being used
•-Participants may not have an active hepatitis B or C infection
•-Chronic hepatisis B or C for which treatment with (peg)interferon and/or ribavirine (Note: patients with untreated chronic hepatitis B or C can be included)
•-They may not use immune suppressive ot immune modulating medication
•-Radiotherapy or chemotherapy in the past 2 years
•-Pregnancy or breastfeeding an infant
•-Participation in other studies

发起方

niversitair Medisch Centrum Utrecht