Fatty Liver and Obstructive Sleep Apnea

Not Applicable

Completed

• Conditions: Non-Alcoholic Fatty Liver Disease; Obstructive Sleep Apnea
• Interventions: Device: Continuous positive airway pressure

• Registration Number: NCT00730873
• Lead Sponsor: Assaf-Harofeh Medical Center

Brief Summary

Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea. Computerized tomography can be used to quantify fatty liver changes. We hypothesize that continuous positive airway pressure can reduce morphologic fatty liver changes in patients with obstructive sleep apnea and non-alcoholic fatty liver, an that this reduction can be evident using computerized tomography

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-08
• Study First Submitted: 2008-08-06
• Study First Submitted QC: 2008-08-07
• Last Update Submitted: 2008-08-07
• Study First Posted: 2008-08-08
• Last Update Posted: 2008-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Obstructive sleep apnea, defined as AHI>5/h

Exclusion Criteria

• Consumption of more than 20 grams of alcohol per 24 h
• Known autoimmune disease
• Usage of known hepatotoxic drugs
• Medical history positive for viral hepatitis or other chronic liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	Continuous positive airway pressure	continuous positive airway pressure

Primary Outcome Measures

Name	Time	Method
Reduction in fatty liver changes on computerized tomography	Within 1-2 years

Secondary Outcome Measures

Name	Time	Method
Improved liver enzymes abnormalities	Within 1-2 years

Trial Locations

Locations (1)

The pulmonary institute, Asaf Harofeh Medical Center; 🇮🇱 Zerifin, Israel