THE EFFECT OF LOW DOSE INTRAVENOUS KETAMINE ON POSTOPERATIVE PAIN FOLLOWING CESAREAN SECTION WITH SPINAL ANESTHESIA
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Degree of post operative pain relief with single dose of intravenous ketamine during cesarean section
研究概览
简要总结
Cesarean section is one of the most common surgeries in the world. Controlling the postoperative pain and getting the new mother out of bed and moving as early as possible following the surgery will reduce the respiratory, cardiovascular, urinary and digestive side effects of surgery.
Opioids such as morphine and pethidine are most commonly used premeditations for postoperative pain. However opioids have numerous side effects such as addiction, respiratory depression, drug resistance, nausea and vomiting. Therefore, use of non-opioid analgesics for postoperative pain is preferred.
In this study we examine the effect of intravenous low dose ketamine on postoperative pain and need for analgesics, including opioids, following cesarean section with spinal anaesthesia using bupvicaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •ASA I to II Patients Female patients.
- •Aged between 20 to 40years.
- •Normal liver and renal function test, Coagulation profile.
- •Undergoing Lower Segment Caesarean Section Surgery.
排除标准
- •Patients with history of allergy to local Anaesthetics.
- •Patients with history of mental disorders.
- •Patient Refusal.
- •Morbid obesity, Coagulopathy and significant cardiovascular respiratory, renal, hepatic or metabolic diseases or CNS disorders.
- •Patients with hypertensive disorder due to any cause ( PIH).
结局指标
主要结局
Degree of post operative pain relief with single dose of intravenous ketamine during cesarean section
时间窗: A visual analogue score will be used to record the participants pain score at 1, 2, 6, 12 hours following surgery. Participants will be asked to rate the intensity of their pain in the scale of one (no pain at all) to 10 (very intense and unimaginable pain).
次要结局
- First rescue analgesia used.(Total analgesic consumed in first 24hrs)