Temporal percpeption of patients suffering from Essential Tremor with and without Deep Brain Stimulatio

Not Applicable

• Conditions: G25.0; Essential tremor

• Registration Number: DRKS00004928
• Lead Sponsor: Klinik und Poliklinik für NeurologieUniversitätsklinik zu Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06-03
• Study Completion: 2014-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Age- and sex-matched control probands:
Age between 18-80 years

ET-patients without Deep Brain Stimulation:
Patients with essential tremor (ET) fulfilling the criteria of the consensus statement of the Movement Disorder Society
Age between 18-80 years
Disease duration of at least 5 years

ET-patienten with Deep Brain Stimulation:
Patients with essential tremor (ET) fulfilling the criteria of the consensus statement of the Movement Disorder Society and DBS for at least 3 months
Age between 18-80 years
Disease duration of at least 5 years
Electrode localisation in the ventrolateral thalamus or areas just below (posterior subthalamic area, PSA)
Tolerabel tremor after switching off the stimulation

Exclusion Criteria

Age- and sex-matched controls:
Subjects with a severe neurologic disease (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia)
Conspicuities in the MRI
Medication affecting cognition which cannot be withdrawn for at least 24 hours
Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease
DemTect < 9
Severe depression

ET-patients without Deep Brain Stimulation:
Patients with a severe neurologic disease other than essential tremor (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia)
Conspicuities in the MRI
Medication affecting cognition which cannot be withdrawn for at least 24 hours
Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease
DemTect < 9
Severe depression

ET-patients with Deep Brain Stimulation:
Patients with a severe neurologic disease other than essential tremor (e.g. epilepsy, brain tumor, ischaemic stroke, dystonia)
Medication affecting cognition which cannot be withdrawn for at least 24 hours
Hypokinesia or resting tremor possibly indicating an underlying Parkinson's disease
DemTect < 9
Severe depression

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time perception is measured with a self programmed software once in ET-patients and control subjects. Additionally, ET-patients with DBS are tested during three different stimulation regimes in a randomized order.

Secondary Outcome Measures

Name	Time	Method
Fahn Tolosa Marin Tremor Rating Score (TRS) is measured objectively via Video ratings and ultrasound based measurements