ISRCTN67819491
Completed
N/A
Myocardial perfusion and microvascular dysfunction in stable coronary artery disease during hyperoxaemia
niversity of Leeds (UK)0 sites90 target enrollmentAugust 14, 2014
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Leeds (UK)
- Enrollment
- 90
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Known coronary artery disease involving one or more major epicardial vessels (\=2\.5mm diameter) with severe coronary artery disease (coronary luminal stenosis severity \=70% or FFR \=0\.8\).
- •For the healthy volunteer group:
- •No known risk factors for underlying coronary artery disease
Exclusion Criteria
- •1\. Clinically unstable
- •2\. Previous coronary artery bypass grafting
- •3\. Contraindication to adenosine (regular adenosine antagonist medication, significant reversible airways disease, second or third degree atrioventricular heart block, sinoatrial disease)
- •4\. Pregnancy or breast feeding
- •5\. Recent acute coronary syndrome (\<6 weeks)
- •6\. Nonsinus rhythm
- •7\. Chronic obstructive airways disease with a history of hypercapnic respiratory failure
- •8\. Three vessel coronary artery disease
- •9\. Claustrophobia
- •10\. Known adverse reaction to adenosine or iodinated contrast agents
Outcomes
Primary Outcomes
Not specified
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