Myocardial perfusion and microvascular dysfunction in stable coronary artery disease during hyperoxaemia

Not Applicable

Completed

• Conditions: Topic: Cardiovascular disease; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Circulatory System

• Registration Number: ISRCTN67819491
• Lead Sponsor: niversity of Leeds (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-14
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients:
Known coronary artery disease involving one or more major epicardial vessels (=2.5mm diameter) with severe coronary artery disease (coronary luminal stenosis severity =70% or FFR =0.8).

For the healthy volunteer group:
No known risk factors for underlying coronary artery disease

Exclusion Criteria

1. Clinically unstable
2. Previous coronary artery bypass grafting
3. Contraindication to adenosine (regular adenosine antagonist medication, significant reversible airways disease, second or third degree atrioventricular heart block, sinoatrial disease)
4. Pregnancy or breast feeding
5. Recent acute coronary syndrome (<6 weeks)
6. Nonsinus rhythm
7. Chronic obstructive airways disease with a history of hypercapnic respiratory failure
8. Three vessel coronary artery disease
9. Claustrophobia
10. Known adverse reaction to adenosine or iodinated contrast agents

Study & Design

• Study Type: Interventional
• Study Design: Not specified