Effect of sivelestat, a neutrophil elastase inhibitor on cardiac surgical patients after cardiopulmonary bypass
Not Applicable
- Conditions
- cardiac and aortic disease
- Registration Number
- JPRN-UMIN000036507
- Lead Sponsor
- ippon Medical School
- Brief Summary
In the control group, the levels of PMN elastase, IL-6, IL-8 in BAL showed a increase after CPB initiation, and were maintained at high levels 3 hours after CPB. In contrast, the sivelestat group had lower concentrations of PMN elastase, IL-6, IL-8 during and after CPB. The reduction in PaO2/FiO2 ratio after CPB was strongly related to the increase in IL-8, IL-6 or the elevation in PMN elastase.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
shock, pulmonary edema, liver dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method perioperative cytokine in bronchial bronchiolar lavage fluid, pulmonary function, oxygenation.
- Secondary Outcome Measures
Name Time Method myocardial injury, hemodynamics, perioperative cytokine in blood