Evaluating the Adherence to Guidelines' Empirical Antibiotic Recommendations and Outcome of Patients Admitted to a Hospital Ward With a Diagnosis of Community-acquired Pneumonia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Community Acquired Pneumonia
- Sponsor
- Capital Medical University
- Enrollment
- 3000
- Locations
- 1
- Primary Endpoint
- in-hospital clinical failure rate
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China
Detailed Description
In China, the data about current management of patients hospitalized with community acquired pneumonia (CAP) in the real-life setting is not available,type of pneumonia, selection of initial antibiotic, time to clinical stability, antibiotic choice anf modification,clinical outcomes and costs remain unclear. In this study, we will collect comprehensive information on CAP and healthcare associated pneumonia (HCAP) management patterns to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China .to analyze microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of patients with CAP (\> and = 65 years, different comorbidities ,risk factors) ,to investigate microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of disease severity with CAP ,to provide the difference on microbiological characteristics,clinical manifestations,antibiotic regimens ,and outcome between patients with CAP and HCAP ,to understand the current situation of antibiotic regimen ,to evaluate influence of different antibiotic regimens on prognosis.
Investigators
Bin Cao
MD
Capital Medical University
Eligibility Criteria
Inclusion Criteria
- •Patients \> or = 14 years of age
- •Patient meets the criteria of community acquired pneumonia
- •Patient meets the criteria of healthcare-associated pneumonia
- •Informed consent to participate in the study is provided
Exclusion Criteria
- •Patients participating in a clinical trial or other intervention studies
- •Patients \<14 years of age
- •Patient meets the criteria of hospital acquired pneumonia
- •Known active tuberculosis or current treatment for tuberculosis
- •Non-infectious pulmonary diseases （e.g. pulmonary embolism, pulmonary edema, pulmonary vasculitis, interstitial pneumonia）
- •HIV positive
Outcomes
Primary Outcomes
in-hospital clinical failure rate
Time Frame: Time from date of admission to discharge up to 1 week
1)a change in antibiotic therapy due to worsening signs or symptoms of infection or lack of clinical improvement, 2) in-hospital mortality, 3) recurrence, defined as signs or symptoms of infection after completion of therapy requiring re-initiation of antibiotics
30-day post-discharge clinical failure rate
Time Frame: discharge up to 5 weeks
rate of re-hospitalization due to pulmonary infection and death during the follow-up period at 30 days post-discharge from hospital
initial antibiotic treatment failure rate
Time Frame: 72 hours
a change in antibiotic therapy due to worsening signs or symptoms of infection or lack of clinical improvement after first dose use of antibiotics to 72h
Secondary Outcomes
- Duration of antimicrobial therapy(6 weeks)
- Days of each antimicrobial therapy(6 weeks)
- Hospital length of stay(2 weeks)
- Duration of intravenous antimicrobial therapy(2 weeks)
- Duration of oral antimicrobial therapy(2 weeks)