Management in Real-life of Patients Hospitalized With Community-acquired Pneumonia in China
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 3,000
- Locations
- 1
- Primary Endpoint
- treatment failure at 72h after initiation of antibiotics
Study Overview
Brief Summary
The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and healthcare-associated pneumonia (HCAP) in real life of China .
Detailed Description
In China, the data about current management of patients hospitalized with CAP in the real-life setting is not available,type of pneumonia, selection of initial antibiotic, time to clinical stability, antibiotic choice anf modification,clinical outcomes and costs remain unclear.
In this study, we will collect comprehensive information on CAP and HCAP management patterns to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China .to analyze microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of patients with CAP (> and = 65 years, different comorbidities ,risk factors) ,to investigate microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of disease severity with CAP ,to provide the difference on microbiological characteristics,clinical manifestations,antibiotic regimens ,and outcome between patients with CAP and HCAP ,to understand the current situation of antibiotic regimen ,to evaluate influence of different antibiotic regimens on prognosis.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 14 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients > or = 14 years of age
- •Patient meets the criteria of community acquired pneumonia
- •Patient meets the criteria of healthcare-associated pneumonia
Exclusion Criteria
- •Patients <14 years of age
- •Patient meets the criteria of hospital acquired pneumonia
- •Known active tuberculosis or current treatment for tuberculosis
- •Non-infectious pulmonary diseases
- •HIV positive
Outcomes
Primary Outcomes
treatment failure at 72h after initiation of antibiotics
Time Frame: Time from the first dose use of antibiotics to 72 hours
treatment failure was defined as a change of antibiotics due to worsening signs or symptoms associated with pneumonia
in-hospital treatment failure due to multiple causes
Time Frame: Time from date of admission to discharge up to 1 week
1)death in hospital;2)change of antibiotics due to worsening signs or symptoms of infection, 3) recurrence, defined as signs or symptoms of infection after completion of therapy requiring re-initiation of antibiotics
Secondary Outcomes
- in-hospital mortality(2 weeks)
- Duration of intravenous antimicrobial therapy(2 weeks)
- Hospital length of stay(2 weeks)
Investigators
Bin Cao
MD
Capital Medical University