Development of a Family-Based Treatment for Adolescent Methamphetamine Use

Phase 1

Completed

• Conditions: Methamphetamine Disorders; Behavior and Mental Disorders
• Interventions: Behavioral: Functional Family Therapy (FFT); Behavioral: Adolescent Methamphetamine Treament (AMT)

• Registration Number: NCT00680511
• Lead Sponsor: Oregon Research Institute

Brief Summary

The AIMS study compares a methamphetamine-specific treatment intervention to a treatment-as-usual Functional Family Therapy (FFT) approach for adolescents ages 15 to 19. Adolescents are assigned to one of two treatment conditions: (1) 16 weeks of FFT designed to strengthen family relationships and develop skills for helping the adolescent avoid drug use; or (2) 16 weeks of a combination of FFT and a methamphetamine-specific intervention involving group and individual therapy sessions; Families are assessed using questionnaires and interviews, and adolescents participate in neuropsychological testing, before, during, and after treatment to provide information about family functioning, the adolescent's drug use, the adolescent's peers, and other factors that may contribute to treatment success. Adolescents also provide urine specimens for drug screening at assessment visits. Through a partnership with Oregon Health and Science University (OHSU), adolescents will participate in functional magnetic resonance imaging appointments at the hospital to examine regional brain blood flow during tasks designed to measure impulsivity and risk-taking behaviors. As a treatment development grant, study investigators will study adolescents' acceptance of and response to the newly developed methamphetamine-specific treatment approach.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-09
• Study First Submitted: 2008-05-16
• Study First Submitted QC: 2008-05-19
• Study First Posted: 2008-05-20
• Primary Completion: 2013-09
• Study Completion: 2013-12
• Status Verified: 2014-08
• Last Update Submitted: 2014-08-04
• Last Update Posted: 2014-08-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 15 to 19 years of age.
• Have at least one parent or parent figure willing to participate.
• Meet DSM-IV diagnostic criteria for drug-abuse or dependence, including a specific meth use disorder.
• Reports meth use on at least 5 of the previous 90 days.
• Have contact with the parent on at least 40% of the past 90 days.
• With their parent be willing to accept randomization to one of the two treatment interventions.
• Be willing to participate in the imaging task in the fMRI pilot study.
• Have basic English competency.
• Have sufficient residential stability to permit probable contact at follow-up.

Exclusion Criteria

• Evidence of psychotic or organic state of sufficient severity to interfere with understanding of study instruments and procedures.
• Have a medical or psychological condition that would preclude undergoing the fMRI scan.
• Have a sibling who is participating in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	Functional Family Therapy (FFT)	Family Therapy.
1	Adolescent Methamphetamine Treament (AMT)	Family therapy combined with methamphetamine-specific group treatment.

Primary Outcome Measures

Name	Time	Method
Substance Use	6 months

Secondary Outcome Measures

Name	Time	Method
Engagement and retention of adolescent methamphetamine users.	6 months

Trial Locations

Locations (1)

Oregon Research Institute Center for Family and Adolescent Research; 🇺🇸 Portland, Oregon, United States