Salivary Bacterial Profiles in Relation to Periodontal Treatment

Not Applicable

Completed

• Conditions: Periodontitis
• Interventions: Procedure: Conventional periodontal treatment

• Registration Number: NCT02913248
• Lead Sponsor: University of Copenhagen

Brief Summary

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

Detailed Description

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Study Timeline

• Study First Submitted: 2016-09-20
• Study First Submitted QC: 2016-09-22
• Study First Posted: 2016-09-23
• Study Start: 2016-10
• Primary Completion: 2017-01-02
• Study Completion: 2017-01-02
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-02
• Last Update Posted: 2017-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Manifest chronic periodontitis according to international classification

Exclusion Criteria

• Other treatment requiring oral conditions
• Systemic antibiotics within the latest 6 months
• Systemic diseases and medications with known associations to periodontitis
• Pregnancy and breastfeeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Conventional periodontal treatment	Conventional periodontal treatment	35 subjects diagnosed with manifest periodontitis, which will all receive standardized treatment according to protocol. In brief, this treatment includes professional tooth cleaning and thorough instruction in self-performed oral hygiene procedures. Clinical registrations and collection of microbiological samples (subgingival and saliva) will performed at baseline and 2, 6 and 12 weeks after treatment.

Primary Outcome Measures

Name	Time	Method
Changes in α-diversity in saliva samples collected .	Baseline and 12 weeks	Comparison of α-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment

Secondary Outcome Measures

Name	Time	Method
Specis specific changes in saliva samples collected	Baseline and 12 weeks	Comparison of relative abundance of bacterial species in saliva samples collected before periodontal treatment to samples collected 12 weeks after treatment

Trial Locations

Locations (1)

University of Copenhagen, Department of Odontology; 🇩🇰 Copenhagen, Denmark