Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA
Completed
- Conditions
- Brain InjuriesHypertensive Intracerebral HemorrhageIntraventricular Hemorrhage
- Interventions
- Drug: intraventricual recombinant tissue plasminogen activator application
- Registration Number
- NCT03452722
- Lead Sponsor
- University of Rijeka
- Brief Summary
This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group. The inflammatory mediator concentration is analyzed in local cerebrospinal liquor.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 88
Inclusion Criteria
- Subjects with primary ICH with IVH
- ICH score 2-4, , with origin of the hematoma in the basal ganglia and blood in the third and/or ventricle
- Patient is not considered a surgical candidate by neurosurgery service
Exclusion Criteria
- No history of diseases or drugs that affect the immunological system.
- ICH score 1 and 5
- Current participation in another research drug treatment protocol
- Previously known intracranial arteriovenous malformation or aneurysms
- Intracerebral hematoma considered to be related to trauma
- ICH is located in the pons
- Blood in the subarachnoid space visualized on CT scan
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Study group intraventricual recombinant tissue plasminogen activator application Applied rtPA
- Primary Outcome Measures
Name Time Method Cytokine concentration difference between two groups Samples taken on day 0, day 1, day 3 and day 7. Cytokine concentration measured from CSL
- Secondary Outcome Measures
Name Time Method