IRCT20190526043711N1
Recruiting
Phase 2
The effect of combination therapy of vitamin E and C supplements plus Platelet-Rich Plasma-Fibrin Glue on biochemical factors, oxidative stress markers and wound healing rate in diabetic patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Mashhad University of Medical Sciences
- Enrollment
- 24
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with grade 2\- 4 diabetic wounds based on Wagner's classification
- •Having wounds on the legs and extremities
- •No smoking, alcohol or drug addiction
- •Non\-use of drugs that may interfere with wound healing, such as corticosteroids, immunosuppressive agents, and cytotoxic agents.
- •Not having an illness that may cause problems in wound healing, such as cancers, vasculitis
- •Age between 40 and 75 years
- •HbA1c over 7 within last 3 months
- •At least 4 weeks have elapsed since the wounds occurred
Exclusion Criteria
- •The presence of ulcer with active infection and the need for intravenous antibiotics
- •Gangrene which needs amputation
- •Lack of patient referral to the center for tracking and changing dressings in more than two occasions
- •Previous consumption of vitamin E and C supplements
- •Patients with renal and hepatic failure and heart failure
- •Patients with advanced diabetic retinopathy
- •Pregnancy or breastfeeding
- •HbA1c more than 11
- •Occurrence of special medical conditions
Outcomes
Primary Outcomes
Not specified
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