Influence of polymorphisms on the sod3, ppara genes on physical performance and redox balacing of runners supplemented with a single dose of grape juice
- Conditions
- RunningAthletesExerciseGeneticsNutritional Supplementation
- Registration Number
- RBR-4d9dmqz
- Lead Sponsor
- fpb - Universidade Federal da Paraiba
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion criteria were defined as: athletes should have been training for at least one year with a frequency of at least four weekly sessions and for at least two months without interruption and taking part in competitions regularly. They also should not have any chronic condition or degenerative diseases, did not smoke, and were not using any long-term medication.
Participants should not consume purple grapes or their derivatives often; and/or dietary supplements, vitamins or bioactive substances present in the grape (polyphenols). Athletes who suffered from skeletal muscle injuries, altered dietary habits or had inconsistent training patterns, started using medication or did not perform some of the study experimental procedures were also excluded.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of the performance in athletes in the treadmill running test, after supplementation with 10ml / kg of grape juice.;Significantly higher 10.1% improvement in performance (running time on a treadmill) after supplementation with grape juice compared to the control drink (57.2 ± 17.6 versus 54.0 ± 18.9 minutes, p < 0.02; d = 0.17.<br><br>9.0% improvement in performance (running time on a treadmill) in the group with GG + CG genotypes of the SOD3 gene compared to the CC genotype (58.4 ± 18.7 vs 53.8 ± 14.2; 3 , 4 ± 9.7 minutes more, p <0.03; d = 0.70.
- Secondary Outcome Measures
Name Time Method A slight difference was noted in Total Antioxidant Capacity (TAC), since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values were not increased compared to the CG+GG group, respectively. ;The SOD3 and PPARa genes were similar at all times for the other biochemical variables (malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH)