Leipzig Artherobesity Childhood Cohort
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- University of Leipzig
- Enrollment
- 200
- Locations
- 2
- Primary Endpoint
- cardiovascular dysfunction
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The investigators hypothesize that cardiovascular and metabolic alterations due to obesity already manifest at childhood age.
To identify these alterations and risk factors, the investigators have established a cohort of 177 healthy obese and lean control children, age ranging from 6y to 18y, for evaluation of cardiovascular and metabolic parameters, as well as quantification of biomarkers of obesity and inflammation. Follow-up analyses are planned after 2 years (completed) and additionally after 5, 7 and 9 years.
In addition, the investigators will assess the effects of increased physical activity and exercise on cardiovascular function.
Investigators
Antje Koerner, Prof. Dr. med.
Prof. Dr. med.
University of Leipzig
Eligibility Criteria
Inclusion Criteria
- •height -2 to +2 SDS
- •pubertal stage adequate for age
- •no medications
- •written consent of guardians and children≥12y
- •weight ≥ -2 SDS
Exclusion Criteria
- •secondary/syndromal obesity
- •known existing hypertension
- •chronic disease (eg. errors of metabolism)
- •acute illness (eg. respiratory tract infection)
- •previous hypertensive or antidiabetic treatment- weight loss attempts 6 weeks prior to assessment
Outcomes
Primary Outcomes
cardiovascular dysfunction
Time Frame: 7 years
Assessment of endothelial function, carotid intima media thickness, blood pressure, echocardiography, exercise capacity, insulin sensitivity by oGTT, serum lipids