Leipzig Artherobesity Childhood Cohort
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- cardiovascular dysfunction
研究概览
简要总结
The investigators hypothesize that cardiovascular and metabolic alterations due to obesity already manifest at childhood age.
To identify these alterations and risk factors, the investigators have established a cohort of 177 healthy obese and lean control children, age ranging from 6y to 18y, for evaluation of cardiovascular and metabolic parameters, as well as quantification of biomarkers of obesity and inflammation. Follow-up analyses are planned after 2 years (completed) and additionally after 5, 7 and 9 years.
In addition, the investigators will assess the effects of increased physical activity and exercise on cardiovascular function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •height -2 to +2 SDS
- •pubertal stage adequate for age
- •no medications
- •written consent of guardians and children≥12y
- •weight ≥ -2 SDS
排除标准
- •secondary/syndromal obesity
- •known existing hypertension
- •chronic disease (eg. errors of metabolism)
- •acute illness (eg. respiratory tract infection)
- •previous hypertensive or antidiabetic treatment- weight loss attempts 6 weeks prior to assessment
结局指标
主要结局
cardiovascular dysfunction
时间窗: 7 years
Assessment of endothelial function, carotid intima media thickness, blood pressure, echocardiography, exercise capacity, insulin sensitivity by oGTT, serum lipids
次要结局
未报告次要终点
研究者
Antje Koerner, Prof. Dr. med.
Prof. Dr. med.
University of Leipzig