Comparison of Nebulised Ropivacaine 0.75 percent Versus Nebulised Dexmedetomidine and Nebulised lignocaine 4 percentin patients undergoing surgery under General Anesthesia.
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Monitor the hemodynamic changes in patients received ultrasonic nebulisation 4 % lignocaine at 10 minutes before and after nebulisation, 10 min, 20 minutes , 30 minutes till 120 minutes after intubation
研究概览
简要总结
This is a prospective, comparative study to monitor the hemodynamic changes in patients received nebulisation lignocaine 4%, dexmedetomidine 1 microgram /kg at the time of intubation , extubation and any cough response.
The response at noted in tabular form and being observed
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade I and II
- •Non- hypertensive 3.Non obese 4.MPC I and II 5.Surgeries lasting for at least upto 2 hours and not beyond 4 hours.
- •Elective surgeries.
排除标准
- •1.Patients who refused to participate in study 2.patients age is less than 18 and not more than 60 years.
- •Patients with nasogastric tube.
- •4.Contraindication for the use of nitrous oxide.
- •5.Mallampati classification III and IV 6.hypertensive patients 7.ASA III AND IV 8.Patients with history of allergy to dexmedetomidine.
- •9.Daycare surgeries.
- •Patients with difficult airway where the anticipated duration of laryngoscopy exceeded 15 seconds.
- •Emergency surgeries.’ 12.Patients with history of cardiac,liver or renal disorders.
结局指标
主要结局
Monitor the hemodynamic changes in patients received ultrasonic nebulisation 4 % lignocaine at 10 minutes before and after nebulisation, 10 min, 20 minutes , 30 minutes till 120 minutes after intubation
时间窗: Observed assessed by 12 weeks
Monitor the hemodynamic changes of patients received ultrasonic nebulisation of dexmedetomidine 1 micro gram per kg at 10 minutes before and after nebulisation.
时间窗: Observed assessed by 12 weeks
10 minutes, 20 minutes, 30 minutes till 90 minutes after intubation.
时间窗: Observed assessed by 12 weeks
Monitor hemodynamic changes in patients received ultrasonic nebulisation of 0.75 % ropivacaine at 10 minutes before and after nebulisation.
时间窗: Observed assessed by 12 weeks
10 minutes, 20 minutes till 90 minutes after intubation.
时间窗: Observed assessed by 12 weeks
次要结局
- To compare the hemodynamic parameters of nebulised ropivacaine versus nebulised lignocaine versus nebulised dexmedetomidine at extubation(With 24 hours.)
研究者
Aysath nuhaimah
B.j medical college , Sassoon hospital